Table 4.
Effect sizes for longitudinal changes in HRQOL measures reported by subjects treated for active TB
| Author [reference] | Instrumenta | Time1 (T1) | Time2 (T2) | Time3 (T3) | Effect size, T1–T3 | Effect size, T1–T2 | Effect size, T2–T3 |
|---|---|---|---|---|---|---|---|
| Dhingra [13] Dhingra [14] | DR-12 | Start of TB treatment | 2 months treatment | End of treatment | 2.05b | 1.72b | 0.56b |
| Dhuria [15] | WHOQOL-BREF | Start of TB treatment | 3 months treatment | End of treatment | 1.51b | 1.03b | 0.58b |
| Kruijshaar [29] | SF-36—PCS | TB diagnosis | 2 months treatment | – | – | 0.23 | – |
| Kruijshaar [29] | SF-36—MCS | TB diagnosis | 2 months treatment | – | – | 0.72b | – |
| Kruijshaar [29] | STAI-6 | TB diagnosis | 2 months treatment | – | – | 0.24 | – |
| Kruijshaar [29] | CES-D | TB diagnosis | 2 months treatment | – | – | 0.72b | – |
| Maguire [32] | Modified SGRQ | TB diagnosis | 2 months treatment | 6 months treatment | 2.64b | 1.80b | 0.97b |
| Marra [33] | SF-36, PCS | TB diagnosis | – | 6 months treatment | 0.06 | – | – |
| Marra [33] | SF-36, MCS | TB diagnosis | – | 6 months treatment | 0.19 | – | – |
| Marra [33] | BDI | TB diagnosis | – | 6 months treatment | 0.31 | – | – |
aWHOQOL-BREF is the World Health Organization’s Quality of Life BREF. SF-36 PCS and MCs are the physical and mental component scores of the Short-Form 36 questionnaire, respectively. STAI-6 is the State-Trait Anxiety Inventory Short Form. CES-D is the Center for Epidemiologic Studies Depression Scale. Modified SGRQ is a modified version of the St. George’s Respiratory Questionnaire. BDI is the Beck Depression Inventory
bMeaningful change in HRQOL scores as defined by Cohen’s criteria [8, 43]