Table 1.

Computationally predicted integirn α subunits-targeting miRNAs were identified using MicroRNA (www.microrna.org) and confirmed by Targetscan online software (www.targetscan.org). All sequences of target genes were defined by microRNA score < −0.1 and by TargetScan context+ score > 80.

Gene symbol	ID	Chromsome site	miRNA	Target sequence	micrrna score	TargetScan Convert+ score*	Conserved condition
ITGA1	Integrin alpha 1	chr5 (q11.2)	hsa-miR-200b	UCUUU-GCUGAGCAGCU	−1.2825	99	P
			hsa-miR-200c	CAAUUUUCCAUUUCAGUAUU	−1.2825	99	P
			hsa-miR-429	UUUUCCAUUUCAGUAUU	−1.2816	99	P
			hsa-miR-135a	UUGUCAUGAAAAGCCAU	−0.9526	95	P
			hsa-miR-203	CAUUUCA	−1.0219	86	P
			hsa-miR-329	GCUUUUUAGGUGUGU	−0.9223	95	P
			hsa-miR-362-3p	ACUGCUU-UUUAGGUGUGU	−0.919	96	P
			hsa-miR-135b	UUGUCAUGAAAAGCCAU	−0.9526	96	P
			hsa-miR-10a	CAACUCCUUGG---UACAGGGU	−0.6762	85	P
			hsa-miR-10b	AACUCCUUGGUACAGGGU	−0.3367	86	P
ITGA2	integrin alpha2	chr5 (q11.2)	hsa-miR-195	UUUAUGCUGCU	−0.2991	86	C
			hsa-miR-16	AUUUA--UGCUGCU	−0.2799	88	C
			hsa-miR-15a	UCCAAGCAUG-ACAACUU	−0.2039	83	C
			hsa-miR-15b	UCAAUUUAUGCUGCU	−0.3017	81	C
			hsa-miR-497	UCAAUUUAUGCUGCU	−0.3068	82	C
			hsa-miR-424	UGCUGCU	−0.3042	81	C
			hsa-miR-27a	ACUGUGA	−0.712	88	C
			hsa-miR-27b	ACUGUGA	−0.712	88	C
			has-miR-19a	AAUAUUUCA---AUUUGCAC	−0.844	86	C
			has-miR-19b	AAUAUUUCA---AUUUGCAC	−0.844	86	C
ITGA3	Integrin alpha3	chr17(q21.33)	has-miR-199a-5p	ACACUGG	−0.4432	81	C
			has-miR-199b-5p	ACACUGG	−0.4432	81	C
			has-miR-181a	AGCGACA-C-UUGAAUGU	−0.6484	87	C
			has-miR-181b	AGCGACACU--UGAAUGU	−0.6197	87	C
			has-miR-181c	AGCGACA-CUUGAAUGU	−0.6483	87	C
			has-miR-181d	AGCGACACU--UGAAUGU	−0.6197	87	C
			hsa-miR-101	CAUGGUACUGU	−0.2294	84	C
			hsa-miR-506	GUGCCUU	−0.5015	83	C
			hsa-miR-124	CUCCUUGUGCCUU	−0.505	83	C
ITGA4	integrin alpha4	chr2(q31.3)	has-miR-30a	UUUAAAAGACACUGUUUAC	−0.8	95	C
			has-miR-30b	UGUUUAC	−0.8036	92	C
			has-miR-30c	UGUUUAC	−0.8036	92	C
			has-miR-30d	UGUUUAC	−0.8036	93	C
			has-miR-30e	UAAAAGACACUGUUUAC	−0.8036	95	C
ITGA5	integrin alpha5	chr12(q13.13)	has-miR-26a	CCAGCCCAGAGACAUACUUGA	−0.6745	84	C
			has-miR-26b	GACAUACUUGA	−0.6745	84	C
			hsa-miR-128	CCCAUGCACUGUG	−0.4134	92	C
			hsa-miR-152	CAUGCACUG	−0.2845	91	C
			has-miR-148a	UGCACUG	−0.2845	91	C
			has-miR-148b	AUGCACUG	−0.2845	91	C
			has-miR-367	CUGUUGC--AAGUGCAAU	−1.0428	98	C
			has-miR-92a	CUGUUGCAAGUGCAAU	−1.0535	97	C
			has-miR-92b	CUGUUGCAAGUGCAAU	−2.107	97	C
			has-miR-363	GUUGCAAGUGCAAU	−1.0535	97	C
			has-miR-25	CUGUUGCAAGUGCAAU	−1.0561	97	C
			has-miR-32	AACUCUGUUGCAAGUGCAAU	−1.0482	97	C
ITGA6	integrin alpha6	chr2(q31.1)	hsa-miR-19a	GUUUUGCAC	−0.4404	84	C
			hsa-miR-19b	GUUUUGCAC	−0.4404	84	C
			has-miR-367	CUAAAUGUGCAAU	−0.9819	88	C
			hsa-miR-32	AAC-UA--AAUGUGCAAU	−0.9789	88	C
			hsa-miR-92a	AAAUGUGCAAU	−0.9819	85	C
			hsa-miR-25	GUCUUAAACUAAAUGUGCAAU	−0.9758	84	C
			hsa-miR-363	AAUGUGCAAU	−0.9789	84	C
			hsa-miR-92b	GUGCAAU	−0.9819	84	C
			has-miR-30a	UGUUUAC	−1.2059	87	C
			has-miR-30b	AAUAUAUUUUGUUUAC	−1.2028	87	C
			has-miR-30c	AAAAUAUAUUUUGUUUAC	−1.2028	87	C
			has-miR-30d	UGUUUAC	−1.2075	87	C
			has-miR-30e	UGUUUAC	−1.2059	86	C
			has-miR-143	GUUAAAAAUG--UCAUCUC	−0.9666	94	C
ITGA7	integrin alpha7	chr12(q13.2)	hsa-miR-124	UCCCCGGAAGUGCCUU	−0.5703	95	C
			hsa-miR-506	UCCCCGGAA--GUGCCUU	−0.5389	96	C
ITGA8	integrin alpha8	chr10 (p13)	hsa-miR-8	AGAAGACCAAAG	−0.3072	97	P
			hsa-miR-199a-5p	AACACUGG	−0.571	89	P
			hsa-miR-199b-5p	CAAAGACCUCAAACACUGG	−0.5746	88	P
ITGA9	integrin alpha9	chr3 (p22.2)	hsa-miR-125a-5p	GCAUGGUCAA--CCCUCAGGG	−0.6957	80	C
			hsa-miR-125b	CUCAGGG	−0.6957	80	C
ITGA10	integrin alpha10	chr1(q21.1)	hsa-miR-22	AGUCCUCC--CUGGCAGCU	−0.4393	88	C
ITGA11	integrin alpha11	chr15(q23)	hsa-miR-148a	UCUGGAAUGCACUG	−0.5994	96	C
			hsa-miR-148b	UCUGGAAUGCACUG	−0.5994	96	C
			hsa-miR-152	UCUGGAAUGCACUG	−0.5994	96	C
ITGAD	integrin alpha D	chr16(p11.2)	hsa-miR-382	AAUCAACUUACAUGGAAACAACU	−0.9143	80	P
			hsa-miR-18a	GUGCUA-A-GCACCUU	−0.1672	85	P
			hsa-miR-190	UAAUGU-UUUUACAUAUC	−0.6222	88	P
			hsa-miR-190b	UAAUGUUUUUACAUAUC	−0.2668	89	P
			hsa-miR-365	UAUUUGUGGGCAUU	−0.8989	94	P
ITGAE	integrin alpha E	chr17(p13.2)	hsa-miR-382	AAUCAACUUACAUGGAAACAACU	−0.9143	80	P
			hsa-miR-18a	GUGCUA-A-GCACCUU	−0.1672	85	P
			hsa-miR-190	UAAUGU-UUUUACAUAUC	−0.6222	88	P
			hsa-miR-190b	UAAUGUUUUUACAUAUC	−0.2668	89	P
			hsa-miR-365	UAUUUGUGGGCAUU	−0.8989	94	P
ITGAL	integrin alpha L	chr16(p11.2)	hsa-miR-23a	AAUGUGA	−0.9167	99	C
			hsa-miR-23b	UUAU-CCAAUAAAUGUGA	−0.9167	99	C
ITGAM	integrin alpha M	chr16(p11.2)	hsa-miR-224	UCAAU-GUGACUU	−0.1207	90	P
			hsa-miR-539	CACCA---AU-AUUUCUC	−1.136	98	P
			hsa-miR-186	AUUCUUU	−0.8343	85	P
			hsa-miR-342-3p	AUUCCAUUGUGUGAG	−0.7084	80	P
			hsa-miR-340	UGGUAGCA-UACUUUAUA	−0.77	90	P
			hsa-miR-185	AGCAGC--UUCUCUCC	−0.2405	87	P
ITGAV	integrin alpha V	chr2 (q32.1)	hsa-miR-142-3p	ACACUAC	−0.9501	95	C
			hsa-miR-135a	AUAUCAUAAUGCUUAAAGCCAU	−0.6978	88	C
			hsa-miR-135b	AUAUCAUAAUGCUUAAAGCCAU	−0.6978	90	C
			hsa-miR-25	CAAGUGCAAU	−0.8261	94	C
			hsa-miR-367	GUCAUUGUUCUCAAGUGCAAU	−0.8046	96	C
			hsa-miR-363	AUUGUUCUCAAGUGCAAU	−0.8118	94	C
			hsa-miR-92a	CAAGUGCAAU	−0.8261	94	C
			hsa-miR-92b	CAAGUGCAAU	−0.8261	93	C
			hsa-miR-32	CAUUGUUCUCAAGUGCAAU	−0.8154	94	C
ITGAW	integrin alpha W	not available	not available
ITGAX	integrin alpha X	chr16(p11.2)	hsa-miR-491-5p	GCGAGUUUUCCCCAC	−0.4861	90	P
			hsa-miR-150	CUGCUUCCUGUCUUUGGGAG	−0.5063	97	P
			hsa-miR-103b	ACAGUUCUGAAU-AUGCUGC	−0.6088	99	P
			hsa-miR-425	AGUGAAUUAGUGUCAU	−0.4593	84	P
			hsa-miR-145	AACUGGA	−0.1668	85	P
			hsa-miR-335	UACCGCUCUUG	−0.2027	84	P
ITGA2B	integrin alpha-IIB	chr17(q21.31)	hsa-miR-24	GACUGAGCC	−0.4374	88	P