Table 4.

Predictors of immunologic memory in P1061s.

Variablea	Serotypeb	Memory Response Criterion	Odds Ratio (Confidence Interval)	P-value
Age	1	4–fold response	.63 (.33–.96)c	.03
	6B	Antibody concentration ≥0.5 mcg/mL at entry or week 1	78 (.61–.99)c	.04
	14	Antibody concentration ≥0.5 mcg/mL at entry or week 1	.65 (.43–.90)c	.01
Nadir CD4% prior to HAART	6B	4–fold response	1.08 (1.01–1.16)d	.02
	14	Antibody concentration ≥0.5 mcg/mL at entry or week 1	1.14 (1.01–1.35)d	.04
CD4% at P1024 screening	1	4–fold response	1.44 (1.13–2.20)d	.001
	6B	4–fold response	1.1 (1.02–1.20)d	.02
CD4% at P1061s entry	1	4–fold response	1.39 (1.09–2.05)d	.003
	1	Antibody concentration ≥0.5 mcg/mL at entry or week 1	1.08 (1.00–1.19)d	.04
	14	Antibody concentration ≥0.5 mcg/mL at entry or week 1	1.18 (1.07–1.38)d	.0007
CD19% at P1024 entry	1	Antibody concentration ≥0.5 mcg/mL at entry or week 1	1.39 (1.13–1.91)d	.0003
CD19% at P1061s entry	1	Antibody concentration ≥0.5 mcg/mL at entry or week 1	1.15 (1.00–1.40)d	.05
Logarithm P1024 viral load	1	Antibody concentration ≥0.5 mcg/mL at entry or week 1	.22 (.04–.85)e	.03
	14	Antibody concentration ≥0.5 mcg/mL at entry or week 1	.21 (.04–.84)e	.03
P1024 viral load ≤400 copies/mL (v. >400 copies/mL)	14	Antibody concentration ≥0.5 mcg/mL at entry or week 1	9.6 (1.14–202.19)	.04
P1024 viral load ≤5000 copies/mL (v. >5000 copies/mL)	1	Antibody concentration ≥0.5 mcg/mL at entry or week 1	12.86 (1.69–270.89)	.01
Logarithm P1061s viral load	14	Antibody concentration ≥0.5 mcg/mL at entry or week 1	.30 (.09–.88)e	.03
Logarithm P1024 antibody	6B	4–fold response	3.07 (1.08–10.23)f	.03
Concentration after PCV7-PCV7-PPV (P1024 Week 24)	6B	Antibody concentration ≥0.5 mcg/mL at entry or week 1	6.82 (1.54–42.63)f	.01
	14	Antibody concentration ≥0.5 mcg/mL at entry or week 1	18.3 (2.18–325.15)f	.005

Note: Odds ratios and Profile Likelihood confidence intervals for variables associated with memory with a Likelihood Ratio Test P-value <0.05 in univariate analyses are shown. Memory was analyzed using 2 definitions: antibody concentration ≥0.5 mcg/mL at entry or week 1; 4-fold or greater antibody rise between entry and week 1.

^aOther variables examined included immune stratum, time on P1061s entry HAART regimen, change in HAART due to virologic failure between P1024 and P1061s, logarithm of antibody concentration at P1024 entry, viral load ≤400 copies/mL v. >400 copies/mL at P1061s entry, viral load ≤5000 copies/mL v. >5000 copies/mL at P1061s entry.

^bPredictors for serotype 1 are shown only for subjects who received PPV in P1061s.

^cOdds ratio for every year increase

^dOdds ratio for every 1% increase

^eOdds ratio for every one logarithm (copies/mL) increase

^fOdds ratio for every one logarithm (mcg/mL) increase