Figure 5.

Schematic shows critical signaling pathways regulating NLRP3 priming and activation. Alu RNA-induced NF-κB-mediated transcriptional activation of inflammasome genes (NLRP3 and IL-18) and signaling via P2X7 receptors control NLRP3 inflammasome priming and activation, respectively. Identification of these key signaling events provides critical mechanistic insights into the recent implication of NLRP3 inflammasome activation and IL-18-induced Myd88 signaling in the pathogenesis of GA.⁵