Figure 4.

Effects of PGJ₂ on VEPs in rAION. (A, B) VEPs 2 days post-rAION from the same two animals whose OCT results are shown in Figure 3. (A) The VEP waveform from the eye of the animal in which rAION was induced and then injected immediately with PGJ₂ (dashed line) is nearly identical in amplitude and latency with the waveform from the animal's contralateral naïve (no rAION, uninjected) eye (solid line). (B) The VEP waveform from the eye of the animal in which rAION was induced and then injected immediately with PBS (dashed line) shows a substantial reduction in amplitude and increased latency compared with the fellow naïve eye (solid line). (C) Ratios of amplitudes in the treated versus untreated eye of animals receiving an IVT injection of PBS post-rAION induction (black triangles, n = 6) versus eyes of animals receiving an IVT injection of PGJ₂ post-rAION induction (gray diamonds, n = 6). For clarity, data are shown for 1-week post-rAION; 2- and 4-week data were not significantly different. No significant change from normal is observed in the PGJ₂-treated eyes (P = 0.92), whereas the animals treated with PBS show a 58% decline in the eye with rAION.