Skip to main content
. 2013 Oct 29;7:269–277. doi: 10.4137/CMO.S10594

Table 1.

Inhibitory concentrations (IC50 in nmol) for targets with multitargeted TKIs.

Drug VEGFR1 VEGFR2 VEGFR3 PDGFRα PDGFRβ c-Kit RET RAF FLT3
Axitinib9 0.1 0.2 0.1–0.3 5 1.6 1.7 >1000 NA >1000
Pazopanib24 10 30 47 71 84 74 >1000 NA >1000
Sunitinib25 10 10 10 5–10 10 13 100–200 NA 1–10
Sorafenib26 NA 90 20 50–60 50–60 68 100–150 5–10 46

Abbreviation: NA, Not available.