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. 2013 Nov 7;8:4315–4326. doi: 10.2147/IJN.S51629

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© 2013 Chen et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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In vitro proliferative inhibitive effect of (A) paclitaxel-loaded six-arm star-shaped poly(lactic-co-glycolic acid) nanoparticles (6-s-PLGA-PTX-NPs) and (B) paclitaxel-loaded linear poly(lactic-co-glycolic acid) nanoparticles (L-PLGA-PTX-NPs) at four different concentrations on human aortic smooth-muscle cells.

Notes: The cytostatic effect of paclitaxel (PTX) was dose dependent, and, in general, the 6-s-PLGA-PTX-NPs showed a similar antiproliferative effect to L-PLGA-PTX-NPs within 7 days. However, the 6-s-PLGA-PTX-NPs demonstrated a long-term antiproliferative effect and will require fewer administrations due to the slower release of PTX from six-arm star-shaped poly(lactic-co-glycolic acid).