Table 2.
The influence of different polymer concentrations, ultrasonic times, polyvinyl alcohol (PVA) concentrations, and water and oil phase volume ratios (W/Os) on the size and encapsulation efficiency (EE) of paclitaxel-loaded six-arm star-shaped poly(lactic-co-glycolic acid) nanoparticles
| Number | Preparation parameter
|
Measurement index
|
||||
|---|---|---|---|---|---|---|
| Polymer concentration (mg/mL) | Ultrasonic time (minutes) | PVA concentration (%) | W/O | Size (nm) | EE (%) | |
| 1 | 30 | 2 | 0.5 | 3:1 | 312.4 | 98.1 |
| 2 | 30 | 5 | 1 | 6:1 | 273.0 | 94.6 |
| 3 | 30 | 8 | 2 | 9:1 | 288.4 | 86.3 |
| 4 | 50 | 2 | 1 | 9:1 | 407.8 | 93.6 |
| 5 | 50 | 5 | 2 | 3:1 | 347.5 | 92.7 |
| 6 | 50 | 8 | 0.5 | 6:1 | 340.1 | 97.6 |
| 7 | 100 | 2 | 2 | 6:1 | 445.1 | 97.5 |
| 8 | 100 | 5 | 0.5 | 9:1 | 566.7 | 95.8 |
| 9 | 100 | 8 | 1 | 3:1 | 240.4 | 95.7 |
| R1 | 291.267 | 388.433 | 406.400 | 300.100 | ||
| R2 | 365.133 | 395.733 | 307.067 | 352.733 | ||
| R3 | 417.400 | 289.633 | 360.333 | 420.967 | ||
| Range (size) | 126.133 | 106.100 | 99.333 | 120.867 | ||
| S1 | 93.000 | 96.400 | 97.167 | 95.500 | ||
| S2 | 94.633 | 94.367 | 94.633 | 95.567 | ||
| S3 | 96.333 | 93.200 | 92.167 | 91.900 | ||
| Range (EE) | 3.333 | 3.200 | 5.000 | 4.667 | ||
Notes: R=average particle size at various levels for each factor; S=average EE at various levels for each factor.