Table 3.
Characterization of paclitaxel-loaded six-arm star-shaped poly(lactic-co-glycolic acid) nanoparticles (6-s-PLGA-PTX-NPs) and paclitaxel-loaded linear poly(lactic-co-glycolic acid) nanoparticles (L-PTX-PLGA-NPs) (mean ± standard deviation, n=3)
Sample | Size (nm) | PDI | EE (%) | DL (%) |
---|---|---|---|---|
L-PLGA-PTX-NPs | 298.6±2.7 | 0.260±0.012 | 88.7±0.5 | 8.6±0.7 |
6-s-PLGA-PTX-NPs | 240.4±6.9 | 0.262±0.017 | 95.7±0.3 | 9.5±0.4 |
Note: Bold values indicate a significant reduction in particle size, a higher encapsulation efficiency and drug loading capacity of 6-s-PLGA-PTX-NPs compared to L-PLGA-PTX-NPs.
Abbreviations: DL, drug-loading capacity; EE, encapsulation efficiency; PDI, polydispersity index.