Figure 7.

Diffusion after 2 hours of 55 nm LNCs and Taxol® at different concentrations through Transwell® with mucus or without (A). Effect of the mucus on LNC and Taxol® diffusion (B); that is, the ratio of permeability without mucus/permeability with mucus. Three paclitaxel concentrations are tested for Taxol® (8.4 μg/mL [lavender bar], 16.8 μg/mL [light purple bar], 42 μg/mL [dark purple bar]) and for LNCs (8.4 μg/mL [light blue], 16.8 μg/mL [medium blue], and 42 μg/mL [dark blue]).

Notes: Data are shown as mean ± standard error of the mean (n=3); ^#not quantifiable; *P<0.05.

Abbreviations: LNC, lipid nanocapsule; P_app, apparent permeability.