Table 1.

Summary description of analysis methods.

Fitting method	AMARES (jMRUI)	Gannet	LC-MODEL	Tarquin
DATA format	GE, Philips, Siemens	GE, Philips, Siemens	GE, Philips, Siemens	GE, Philips, Siemens
Frequency correction	Optional automatic processing	Automatic	Optional pre-processing step. Not part of the LC Model package	Optional automatic processing
Water subtraction	Optional semi-automatic processing	Optional automatic processing	Not performed	Optional automatic
Calculation of edited spectrum	Manual	Automatic	Pre-processing required	Automatic
GABA model	User choice – singlet or doublet, prior knowledge for Gaussian or Lorentzian	Singlet, Gaussian	Basis set uses simulated or phantom spectra.	Two Gaussian singlets
Concentration estimates	User choice of reference to water, Cr NAA	Automatic reference to water and Cr	Automatic reference to water or user choice of NAA, Cr	Automatic reference to water or user choice of Cr, NAA
Quality measures	SD of residual	SD of residual, rejection of data with poor quality, or excessive motion	CRLB	SD of residuals
Analysis of non-edited spectrum	Single, or double peak model	Single peak model	Metabolite basis set analysis	Metabolite basis set analysis