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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Vasc Surg. 2013 May 14;58(6):10.1016/j.jvs.2013.02.241. doi: 10.1016/j.jvs.2013.02.241

Figure 1.

Figure 1

Hemotoxylin and eosin staining of the murine hind limb muscle tissue sections following 1.5 hours of ischemia and 48 hours of reperfusion; representative images are shown. (a) TLR4m tissue sections show relatively preserved muscle fibers with scattered fiber injury, indicated by the black arrows, and tissue edema. (b) Wild type tissue sections show significantly greater muscle fiber injury; black arrows indicate examples of injured fibers. (c) There was significantly greater muscle fiber injury in the wild type hind limb muscle groups, gastrocnemius and anterior tibialis, compared to the TLR4m tissues (*p<0.05, **p<0.01, respectively). Increased muscle fiber injury in wild type mice (c) was consistent with significantly decreased ATP levels (d) compared to the less injured, TLR4m group showing much higher ATP levels (*p<0.04). Black bar in (a) and (b) represents 100 microns.