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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Heart Rhythm. 2013 Aug 1;10(11):10.1016/j.hrthm.2013.07.047. doi: 10.1016/j.hrthm.2013.07.047

Figure 5.

Figure 5

Effect of milrinone and cilostazol on action potential duration at 90% repolarization (APD90), epicardial (EDR) and transmural (TDR) dispersion of repolarization in the canine arterially-perfused right ventricular wedge. The combination of NS5806 (5 μM) and verapamil (2 μM) induces heterogeneous loss of the epicardial (Epi) action potential (AP) dome, producing both EDR and TDR. Addition of milrinone (2.5 μM) or cilostazol (5-10 μM) reduces dispersion. APD90, EDR and TDR are measured in case of single stimulated beat with loss of the AP dome at EPI 2 site but not EPI 1. Results are mean ± S.E.M. * p < 0.05 and ** p < 0.01 vs. control. # p < 0.05 and ## p < 0.01 vs. NS5806+verapamil combination (Brugada-model). n=7 for B and D, n=6 for C and E. Endo — endocardial.