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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Heart Rhythm. 2013 Aug 1;10(11):10.1016/j.hrthm.2013.07.047. doi: 10.1016/j.hrthm.2013.07.047

Figure 6.

Figure 6

Effect of milrinone and cilostazol to suppress polymorphic ventricular tachycardia (VT) in a right ventricle wedge model of Brugada syndrome. The combination of NS5806 (5 μM) and verapamil (2 μM) induces heterogeneous loss of the epicardial (Epi) action potential dome. Phase 2 reentry occurs as the dome propagates from Epi 1 to Epi 2, triggering an episode of polymorphic VT. Addition of 2.5 μM milrinone (upper panel) or 10 μM cilostazol (lower panel) abolishes phase 2 reentry and polymorphic VT. Endo — endocardial.