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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Aug 27;1832(12):10.1016/j.bbadis.2013.08.005. doi: 10.1016/j.bbadis.2013.08.005

Figure 1. Survival bar charts of treatments in Δ7 SMA mice and Taiwanese SMA mice.

Figure 1

(A) Survival bar charts comparing control and treatment in Δ7 SMA mice. *, still alive at > 250 days. (B) Survival bar charts comparing control and treatment in Taiwanese SMA mice. **, still alive at > 230 days. References for the studies are denoted in the brackets. Abbreviations: AAV, adeno-associated virus; scAAV, self-complementary adeno-associated virus; coSMN, codono-ptimized SMN; scAAV9-SMNopti, an optimized SMN-encoding scAAV9; IM, intramuscular injection; ICV, intracerebroventricular injection; IV, intravenous injection; IP, intraperitoneal injection; SC, subcutaneous injection; OE, overexpression; PO, per os; TP, transplantation; ASO, antisense oligonucleotide; MOE, an ASO with phophorothioate backbone and 2′-O-methoxyethyl modification; MO, morpholino; 2′-OMe, an ASO with phophorothioate backbone and 2′-O-methyl modification; ISS-N1, intronic splicing silencer N1; PMO, phosphorodiamidate morpholino oligonucleotides; Tra2β1, transformer-2 protein homolog β; SF2/ASF, splicing factor2/alternative splicing factor.