TABLE 2.

Relationship between pregnancy history and serum homocysteine levels

Parameter	Model	Nulliparous	Normotensive pregnancy	HTN pregnancy	P value overall	P value normal vs null	P value HTN vs null	P value HTN vs normal
Log (homocysteine)	Unadjusted	2.24 ± 0.37	2.21 ± 0.32	2.24 ± 0.36	.11	.15	.88	.09
Log (homocysteine)	Age, race, education adjusted	2.26 ± 0.34	2.19 ± 0.30	2.25 ± 0.33	< .001	.002	.69	< .001
Log (homocysteine)	Full	2.26 ± 0.33	2.19 ± 0.29	2.24 ± 0.33	.002	.005	.47	.015
Homocysteine >13 μmol/L	Unadjusted	16%	11%	15%	.012	.018	.74	.011
Homocysteine >13 μmol/L	Age, race, education adjusted	19%	11%	17%	< .001	< .001	.64	< .001
Homocysteine >13 μmol/L	Full	18%	11%	15%	< .001	< .001	.34	.005

HTN, hypertensive.

First 3 rows show mean ± SD of log(homocysteine) in each pregnancy group estimated from linear regression models where serum homocysteine was analyzed as continuous variable with log transformation due to nonnormality. Three models are: unadjusted; adjusted for demographics of age, race, and education; and adjusted for demographics + smoking, HTN, log body mass index, diabetes, dyslipidemia, statins, hormone replacement therapy, family history of HTN, and coronary heart disease. Last 3 rows show proportion of women in each pregnancy group with elevated homocysteine (>13 μmol/L) estimated from logistic regression models with same 3 levels of adjustment. Accounting for sibling relationships is done using generalized estimating equations.