TABLE 4.

Multivariable logistic regression model predicting elevated homocysteine (>13 μmol/L)

Parameter	OR (95% CI)	P value
Normotensive pregnancy (vs nulliparous)	0.49 (0.32–0.74)	< .001
Hypertensive pregnancy (vs normotensive)	1.60 (1.15–2.21)	.005
Race		.78
Non-Hispanic, white	ref
Hispanic	0.88 (0.55–1.42)	.61
Non-Hispanic, black	1.01 (0.70–1.47)	.95
Age, per 10 y	1.76 (1.48–2.08)	< .001
Education level		.009
High school graduate or GED (12 y)	ref
<High school education (≤8 y)	1.60 (1.08–2.37)	.019
Partial high school education (9-11 y)	1.52 (0.99–2.32)	.05
>High school education (>12 y)	0.86 (0.60–1.22)	.40
Ever smoked	1.33 (1.01–1.74)	.043
Current hypertension	2.02 (1.32–3.10)	.001
Diabetes	1.50 (1.13–2.00)	.005
Log (BMI)	1.19 (0.59–2.38)	.62
Dyslipidemia	1.08(0.75–1.53)	.69
Statins	1.04 (0.76–1.43)	.80
Hormone replacement therapy	0.75 (0.53–1.04)	.09
Family history of hypertension	0.95 (0.71–1.28)	.75
Family history of coronary heart disease	1.24 (0.92–1.67)	.15

Data show logistic regression results for OR (95% CI) for having elevated serum homocysteine (>13 μmol/L) accounting for sibling relationships using generalized estimating equations.

BMI, body mass index; CI, confidence interval; GED, general educational development; OR, odds ratio; ref, reference.