. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: J Electrocardiol. 2013 Sep 6;46(6):10.1016/j.jelectrocard.2013.08.006. doi: 10.1016/j.jelectrocard.2013.08.006

Table 2. Features Common to Brugada and Early Repolarization Syndromes and Possible Underlying Mechanisms.

	BrS	ERS	Possible Mechanism(s)
Region Associated with highest arrhythmic risk	RVOT	Inferior myocardium	Increased levels of I_to
Male Predominance	Yes (75%)	Yes (80%)	Testosterone modulation of ion currents underlying the epicardial AP notch
Average age of first event	~35-40	42
Dynamicity of ECG	High	High	Autonomic modulation of ion channel currents underlying early phases of the epicardial AP
VT/VF trigger	Short-coupled PVC	Short-coupled PVC	Phase 2 reentry
Ameliorative response to quinidine	Yes	Yes	Inhibition of Ito and possible vagolytic effect
Ameliorative response to Isoproterenol and cilostazol	Yes	Yes	Increased ICa and faster heart rate
Ameliorative response to pacing	Yes	Yes	Reduced availability of I_to due to slow recovery from inactivation
Vagally-mediated accentuation of ECG pattern	Yes	Yes	Direct effect to inhibit I_Ca and indirect effect to increase I_to (due to slowing of heart rate)

RVOT=right ventricular outflow tract, AP=action potential; PVC=premature ventricular contraction