Figure 1. RNA levels of SP, NK1R, HIV and immune markers in frontal cortex of subjects from HIV-NP− and HIV-NP+ groups.
Total RNA was extracted from frontal cortex of HIV-1 infected subjects with (n=19) or without (n=16) HIV-associated neuropathology and assayed for specific RNA levels by real-time RT PCR. RNA levels are expressed as log10 copies number relative to GAPDH mRNA. Results are presented as data for individual samples and mean. Differences in levels of CXCR4 and CCR5 were compared by independent sample t-tests between the two groups. Mann-Whitney tests were performed to compare differences between SP, NK1R-Full, CCL2 and HIV-1 GAG in the two groups.