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. Author manuscript; available in PMC: 2014 Nov 5.
Published in final edited form as: Structure. 2013 Oct 3;21(11):10.1016/j.str.2013.08.021. doi: 10.1016/j.str.2013.08.021

Figure 4. Structural and functional analyses of Insertions I and II.

Figure 4

(A) Leucine-rich motif of Insertion I (salmon) forms extensive hydrophobic interactions with residues from α3 and α5 (yellow). (B) Structural environment of Insertion II (salmon) near the dimer interface and the active site. (C) Aminoacylation assay indicating that deletion of Insertion I has a larger effect on SerRS aminoacylation activity than deletion of Insertion II. (D) ATP PPi-exchange assay confirming the effect of Insertion I on the active site.