. Author manuscript; available in PMC: 2014 Dec 15.

Published in final edited form as: Anal Biochem. 2013 Sep 14;443(2):10.1016/j.ab.2013.09.009. doi: 10.1016/j.ab.2013.09.009

Table 1.

Summary of the Activity of a Panel of hPXR Ligands

	Activity in This Study, Using BODIPY FL vinblastine as Probe		Activity Reported, Using Fluormone PXR (SXR) Green as Probe

Chemical	IC₅₀	K _i	IC₅₀^a	K _i ^b
TO901317	159 nM	116 nM	44 nM [12], 52 nM [24], 90 nM[13]	22 nM, 26 nM, 45 nM
SR12813	157 nM	114 nM	42 nM [15], 49 nM [11], 69 nM [24], 140 nM [16], 710 nM[13]	21 nM, 24.5 nM, 34.5 nM 70 nM, 355 nM
Clotrimazole	1.94 μM	1.41 μM	2.0 μM [24]	1.0 μM
Rifampicin	12.7 μM	9.26 μM	14.13 μM [24]	7.06 μM
Hyperforin	147 nM	107 nM	140 nM [24], 710 nM [13]	70 nM, 355 nM
Ginkgolide A	13.7 μM	9.99 μM	54% (1000 μM) [14]	NA^c
Ginkgolide B	12.1 μM	8.82 μM	48% (1000 μM) [14]	NA

Values obtained from published reports (see References)

Values calculated from published data by using equation 2 (see Methods)

NA: Not applicable