Table 1.
Ginsenoside | Animal model | Mechanism | Reference |
---|---|---|---|
| |||
Rg1 | Spontaneously hypertensive rat | Repair of glomerular structure | 26 |
UUO | Renal interstitial fibrosis↓ | 25 | |
Repair of peritubular capillary | |||
Thrombospondin-1↓, VEGF↑ | |||
Re | STZ-induced diabetic rat | Oxidative stress↓ | 27 |
Rb1 | Glycerol-induced acute renal failure | Renal function↑ | 28 |
Oxidative stress↓ | |||
Repair of renal morphology | |||
UUO | Oxidative damage↓ | 30 | |
Renal TGF-β1↓ | |||
Renal interstitial fibrosis↓ | |||
Intestinal ischemia reperfusion-induced renal injury | Renal function↑ | 29 | |
Oxidative stress↓ | |||
Nrf2/ARE pathway↑ | |||
Rd | Cisplatin-induced acute renal failure | Renal function↑ | 31-33 |
Cephaloridine-induced renal failure | Oxidative stress↓ | ||
Renal ischemia-reperfusion |
UUO, unilateral ureteral obstruction; VEGF, vascular endothelial growth factor, STZ, streptozotocin; Nrf2, nucuear factor erythroid 2-related factor 2; ARE, antioxidant response element.