Table 1.
Examples of NIMA Matching and NIMA Mismatching in the Setting of a Single Locus Mismatched Umbilical Cord Blood Transplant
HLA-A | HLA-B | HLA-DRB1 | |
---|---|---|---|
NIMA matched* | |||
UCB unit/donor | A*02, 32 | B*18, 35 | DRB1*01:01, 11:04 |
UCB donor mother | A*24, 32 | B*07, 35 | DRB1*01:01, 13:01 |
Recipient | A*02, 24 | B*18, 35 | DRB1*01:01, 11:04 |
NIMA mismatched† | |||
UCB unit/donor | A*02, 32 | B*18, 35 | DRB1*01:01, 11:04 |
UCB donor mother | A*24, 32 | B*07, 35 | DRB1*01:01, 13:01 |
Recipient | A*01, 02 | B*18, 35 | DRB1*01:01, 11:04 |
HLA-A*24 is not carried by UCB donor. HLA-A*24 is carried by the UCB donor’s mother and the recipient; thus, this is an NIMA-matched UCBT.
HLA-A*01 is not carried by UCB donor or the UCB donor’s mother; thus, this is an NIMA-mismatched UCBT.