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RA modulates the immune response. An inflammatory microenvironment can impact and change the phenotype of APCs as a consequence RA production. RA is known for inducing gut-homing properties on T and B lymphocytes, and for influencing the generation and differentiation of different subpopulation of T lymphocytes, which are a crucial arm of the immune response. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
