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. Author manuscript; available in PMC: 2013 Nov 13.
Published in final edited form as: Immunol Rev. 2009 May;229(1):10.1111/j.1600-065X.2009.00782.x. doi: 10.1111/j.1600-065X.2009.00782.x

Fig. 1. CD40 signaling dependent and independent of tumor necrosis factor receptor-associated factor (TRAF) proteins.

Fig. 1

After CD40 activation, TRAFs 1, 2, 3, 5, and 6 are recruited to CD40 tail, driving different signaling pathways. Furthermore, Janus family kinase 3 can bind to the proximal cytoplasmic membrane of CD40. The signaling dependent or independent of TRAF protein regulates different cellular and immune processes.