Table 2.
List of select Velcade regulated genes in MPM cells
| ID | adj.P.Val | FoldChange | Direction | Symbol | Name | Entrez |
|---|---|---|---|---|---|---|
| 1940497 | 0.02984924 | 2.641078795 | DOWN | EPS15L1 | Epidermal growth factor receptor pathway Substrate 15-like 1 | 58,513 |
| 4390747 | 0.2854652 | 2.300179562 | DOWN | HK1 | Hexokinase 1 | 3,098 |
| 3990647 | 0.3404443 | 2.149919083 | DOWN | CLK3 | CDC-like kinase 3 | 1,198 |
| 5720497 | 0.58914674 | 2.294300429 | DOWN | PSMD2 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 5,708 |
| 3190593 | 0.58914674 | 2.106476252 | DOWN | UBR4 | Ubiquitin protein ligase E3 component n-recognin 4 | 23,352 |
| 5340592 | 0.58914674 | 2.056172196 | DOWN | AKAP8L | A kinase (PRKA) anchor protein 8-like | 26,993 |
| 6560482 | 0.58914674 | 2.569074114 | UP | CIRBP | Cold inducible RNA binding protein | 1,153 |
| 6180192 | 0.70227989 | 2.769594163 | DOWN | PSMC4 | Proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 5,704 |
| 5690553 | 0.81019895 | 2.549852512 | DOWN | NDRG1 | N-myc downstream regulated gene 1 | 10,397 |
| 4260441 | 0.86383241 | 2.03400233 | DOWN | UBR1 | Ubiquitin protein ligase E3 component n-recognin 1 | 197,131 |
| 1980458 | 0.87893475 | 3.343181361 | DOWN | RND3 | Rho family GTPase 3 | 390 |
| 5670139 | 0.95625714 | 2.305873036 | DOWN | IER5 | Immediate early response 5 | 51,278 |
| 1940711 | 0.96254178 | 2.135861801 | DOWN | UBFD1 | Ubiquitin family domain containing 1 | 56,061 |
| 2260445 | 0.99968708 | 2.994567021 | DOWN | BAG3 | BCL2-associated athanogene 3 | 9,531 |
| 1940048 | 0.99997172 | 3.560655456 | DOWN | OSGIN1 | Oxidative stress induced growth inhibitor 1 | 29,948 |
| 1990433 | 0.99997172 | 2.270710674 | UP | TFAP2A | Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
7,020 |
| 3850242 | 0.99997172 | 2.142991697 | DOWN | RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | 11,186 |
| 2680291 | 0.99997172 | 2.396075856 | DOWN | HRK | Harakiri, BCL2 interacting protein (contains only BH3 domain) |
8,739 |
| 5340754 | 0.99997172 | 2.820934606 | UP | ANTXR1 | Anthrax toxin receptor 1 | 84,168 |
| 5810471 | 0.99997172 | 2.431797077 | UP | DRAM | Damage-regulated autophagy modulator | 55,332 |
| 5260026 | 0.99997172 | 2.273615266 | UP | ASS1 | Argininosuccinate synthetase 1 | 445 |
| 1710376 | 0.99997172 | 2.549056416 | UP | TANC1 | Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
85,461 |
| 3370167 | 0.99997172 | 2.222452114 | UP | TNFRSF6B | Tumor necrosis factor receptor superfamily, member 6b, decoy |
8,771 |
| 7400408 | 0.99997172 | 2.242145554 | DOWN | SFN | Stratifin | 2,810 |
| 5690370 | 0.99997172 | 2.478611601 | UP | IGFBP2 | Insulin-like growth factor binding protein 2, 36 kDa | 3,485 |
| 3140239 | 0.99997172 | 2.322796252 | DOWN | GADD45A | Growth arrest and DNA-damage-inducible, alpha | 1,647 |
| 3190239 | 0.99997172 | 3.166443653 | UP | CLDN1 | Claudin 1 | 9,076 |
| 2230131 | 0.99997172 | 2.255362514 | UP | PTX3 | Pentraxin-related gene, rapidly induced by IL-1 beta | 5,806 |
| 870358 | 0.99997172 | 2.167596068 | UP | PYCARD | PYD and CARD domain containing | 29,108 |
| 7160711 | 0.99997172 | 2.165129419 | DOWN | PPARG | Peroxisome proliferator-activated receptor gamma | 5,468 |
| 1070403 | 0.99997172 | 2.159964952 | UP | GAS6 | Growth arrest-specific 6 | 2,621 |
| 2600739 | 0.99997172 | 2.115975024 | UP | RARRES1 | Retinoic acid receptor responder (tazarotene induced) 1 | 5,918 |
| 1740341 | 0.99997172 | 2.142555768 | UP | XAF1 | XIAP associated factor 1 | 54,739 |
| 4250379 | 0.99997172 | 2.433203999 | DOWN | FOS | v-fos FBJ murine osteosarcoma viral oncogene homolog | 2,353 |
| 4480019 | 0.99997172 | 2.013663595 | UP | TNFRSF19 | Tumor necrosis factor receptor superfamily, member 19 | 55,504 |
| 3850730 | 0.99997172 | 2.311574067 | UP | CLDN11 | Claudin 11 | 5,010 |
| 6550634 | 0.99997172 | 2.390854775 | UP | RARRES2 | Retinoic acid receptor responder (tazarotene induced) 2 | 5,919 |
| 2970767 | 0.99997172 | 2.424118771 | DOWN | MMP3 | Matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 4,314 |