Table 1.

Common HIV-1 protease cleavage sites.

Site	Location	Substrate peptide sequence (P4-P1 ↓ P1′-P4′)
1	MA-CA	AQNY ↓ PIVQ
2	CA-sp1	ARVL ↓ AEAM
3	sp1-NC	ATIM ↓ MQRG†
4	NC-sp2	RQAN ↓ FLGK
5	sp2-p6	PGNF ↓ LQSR†
6	NC-p6*	RQAN ↓ FLRE†
7	p6*-PR	SFNF ↓ PQIT
8	PR-RT	TLNF ↓ PISP
9	Within RT	AETP ↓ YVDG
10	PR-IN	RKIL ↓ FLDG

^†The sequences are from the HXB2 strain; these sites display sequence polymorphism among different strains.

CA: Capsid; MA: Matrix; NC: Nucleocapsid.