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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Medchemcomm. 2013 Oct;4(10):10.1039/C3MD00219E. doi: 10.1039/C3MD00219E

Scheme 2.

Scheme 2

General synthetic methods. Reagents and conditions: (i) X1X2NH, EDC, HOBT, triethylamine; (ii) H2, 5% Pd/C; (iii) Ac2O, AcOH; (iv) LiBH4; (v) Dess–Martin periodinane; (vi) triethyl phosphonoacetate, NaH; (vii) MeMgBr.