Table 4.

Effects of interdisciplinary therapy in neuroendocrine regulation of energy balance and inflammatory profile.

Variables		Baseline	After therapy	P value	Δ value
Neuroendocrine regulation of energy balance	AgRP (ng/mL)	0.76 ± 1.45	0.55 ± 0.34	<0.001	0.05 ± 0.14
	NPY (ng/mL)	1.42 ± 1.75	1.55 ± 2.28	0.66	0.14 ± 2.82
	NPY/AgRP ratio*	0.41 (0.03–9.1)	0.42 (0.01–5.33)	0.07	0.02 (−2.47–2.86)
	MCH (ng/mL)	4.14 ± 2.42	4.95 ± 2.50	0.80	0.45 ± 1.81
	α-MSH (ng/mL)	0.99 ± 0.54	1.06 ± 0.75	0.03	0.10 ± 0.44
	Ghrelin (ng/mL)	1.10 ± 0.27	1.14 ± 0.24	0.40	0.02 ± 0.17
	Leptin (ng/mL)	42.59 ± 26.62	27.41 ± 20.48	<0.001	−19.77 ± 25.32
Inflammatory profile	Adiponectin (µg/L)	6.61 ± 3.61	7.42 ± 4.61	<0.001	1.63 ± 2.69
	Lep/Adipo ratio*	5.7 (0.15–44.3)	3.7 (0.16–30.9)	<0.001	−10.48 (5.64–36.41)
	TNF-α (ng/mL)	44.31 ± 78.9	29.25 ± 41.45	0.23	−15.05 ± 52.03
	CRP (ng/mL)	6.38 ± 11.34	8.75 ± 14.87	0.48	1.82 ± 17.36
	Resistin (ng/mL)	12.45 ± 10.5	13.10 ± 10.3	0.71	0.22 ± 4.88
	PAI-1 (ng/mL)	13.4 ± 8.1	9.6 ± 8.3	<0.001	−3.94 ± 6.00
	interleukin-6 (IL-6)	58.3 ± 46.9	32.4 ± 21.7	0.05	−25.88 ± 49.85

*Nonparametric data; statistical significance P ≤ 0.05; AgRP: Agouti-related peptide; NPY: neuropeptide Y; MCH: melanin-concentrating hormones; α-MSH: α-melanocyte-stimulating hormone; Lep/Adipo ratio: leptin/adiponectin ratio; TNF-α: tumor necrosis factor-alpha; CRP: C-reactive protein; PAI-1: plasminogen activator inhibitor-1. Reference values: Leptin values between 1 and 20 ng/ml for males and between 4.9 and 24 ng/ml for females.