Table 3.

Crude and adjusted all-cause mortality hazard ratios according to according to whether none, one or two of these antibodies are reduced (anti-PC and aOxCL) based on median values

		All-cause mortality		CVD mortality
Number of deaths		109 (49%)		44 (20%)
	Covariates	HR (95% CI)	P	HR (95% CI)	P
Crude	Zero antibodies reduced (n = 70)	1·00		1·00
	One antibody reduced (n = 61)	1·86 (1·08–3·25)	0·02	1·91 (0·79–4·88)	0·15
	Two antibodies reduced (n = 71)	2·67 (1·63–4·52)	<0·0001	3·13 (1·43–7·53)	0·003
Adjusted	Zero antibodies reduced (n = 70)	1·00		1·00
	One antibody reduced (n = 61)	1·50 (0·83–2·78)	0·17	1·41 (0·56–3·73)	0·45
	Two antibodies reduced (n = 71)	2·04 (1·19–3·61)	0·008	2·23 (0·98–5·53)	0·05
	Age (years)	1·05 (1·03–1·07)	<0·0001	1·03 (0·99–1·06)	0·05
	Sex (men)	1·25 (0·82–1·94)	0·29	1·02 (0·54–1·99)	0·93
	Smoking (yes)	1·20 (0·87–1·66)	0·25	2·64 (1·01–2·05)	0·04
	Vintage (months)	1·01 (0·99–1·02)	0·54	1·01 (0·99–1·01)	0·94
	Comorbidities (Davies score)	4·18 (2·19–8·19)	<0·0001	2·50 (1·49–4·34)	0·0004

CVD: cardiovascular disease; PC: phosphorylcholine; aOxCL: oxidized autoantibodies against cardiolipin; HR: hazard ratio.