Table 7.
Group | Lean | Obese | Tesaglitazar | |||
---|---|---|---|---|---|---|
State | Basal | ClampL | Basal | ClampL | Basal | ClampL |
Content | 33 ± 4 | 40 ± 2 | 43 ± 7 | 49 ± 2 | 33 ± 3* | 41 ± 2 |
R gly | 0.25 ± 0.05 | 3.53 ± 0.91 | 0.38 ± 0.07 | 1.86 ± 0.55† | 0.20 ± 0.02 | 3.99 ± 0.31‡‡ |
Results are mean ± SE (n = 4–8). Groups of animals were studied either in the basal state or during isoglycemic clamps performed at physiological levels of hyperinsulinemia suited to each group (insulin infusion rates as for ClampL in Study 2, defined in Table 3). Data represent values obtained by averaging red gastrocnemius and red quadriceps muscles. Basal state differences; *P < 0.05 versus Obese. Response to insulin (ClampL-Basal) differences; † P < 0.05 Obese versus Lean, and ‡‡ P < 0.01, Tesaglitazar versus Obese.