Table 3.

Correlation between PA diameter measured by CT, PA:A ratio, and hemodynamics

Reference	Study population, n	COPD subjects (%)	CT metric	Endpoint	Results
Ng et al63	50 (heterogeneous)	8 (16%)	PA	mPAP	r=0.74*
				PVR	r=0.55*
			PA:A	mPAP	r=0.74*
				PVR	r=0.59*
Mahammedi et al61	298 (heterogeneous)	17 (5.7%)	PA	mPAP	r=0.51*
			PA:A	mPAP	r=0.54*
Boerrigter et al64	69 (PAH)	0	PA	mPAP	r=0.58*
			PA:A	mPAP	r=0.71*
Devaraj et al68	77 (heterogeneous)	5 (6%)	PA	mPAP	r2=0.45*
			PA:A	mPAP	r2=0.45*
			PA:A + RVSP	mPAP	r2=0.55*
Chan et al69	108 (hospitalized)	2 (2%)	PA >29 mm	mPAP >25 mmHg	OR 4.8*
			PA:A >1	mPAP >25 mmHg	OR 9.1*
Devaraj et al65	30 (ILD)	–	PA	mPAP	r=0.23
			PA:A	mPAP	r=0.54**
	47 (heterogeneous)	5 (10.6%)	PA	mPAP	r=0.67*
			PA:A	mPAP	r=0.72*
Zisman et al66	65 (IPF)	0	PA	mPAP	r=0.148
			PA:A	mPAP	r=0.203
Alhamad et al67	100 (ILD)	–	PA	mPAP	r=0.301*
			PA:A	mPAP	r=0.434*
	34 (heterogeneous)	8 (23.5%)	PA	mPAP	r=0.701*
			PA:A	mPAP	r=0.626*
Heinrich et al73	60 (CTEPH)	0	PA	mPAP	r=0.42*
			PA:A	mPAP	r=0.48*
				PVR	r=0.29**
Iyer et al70	60 (COPD)	100%	PA	mPAP	r=0.60*
			PA:A	mPAP	r=0.56*

Notes:

^*P<0.01;

^**P<0.05.

Abbreviations: mPAP, mean pulmonary artery pressure; PVR, pulmonary vascular resistance; r, Pearson correlation coefficient; PAH, pulmonary arterial hypertension; ILD, interstitial lung disease; IPF, idiopathic pulmonary fbrosis; CTEPH, chronic thromboembolic pulmonary hypertension; OR, odds ratio; COPD, chronic obstructive pulmonary disease; PA, pulmonary artery; PA:A, pulmonary artery to ascending aorta; CT, computed tomography.