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pH i and pH e in normal and cancer cells: apoptosis and antiapoptosis
| Normal cells | Cancer cells | |
|---|---|---|
| |
(pH
i
< pH
e
) |
(pH
i
> pH
e
) |
| |
|
(“proton gradient reversal”)
|
|
Intracellular pH (pH
i
) |
6.99-7.05 |
7.12-7.7 |
| |
|
(Pathological antiapoptosis) |
|
Extracellular/ |
|
|
|
interstitial pH (pH
e
) |
7.35-7.45 |
6.2-6.9 |
| pH i <6-6.5 | (Therapeutic apoptosis) |
