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. Author manuscript; available in PMC: 2013 Nov 13.
Published in final edited form as: Cell. 2011 Sep 2;146(5):10.1016/j.cell.2011.07.032. doi: 10.1016/j.cell.2011.07.032

Figure 7. c-JUN Activity Is Upregulated in AMLs Displaying Constitutive AKT Activation or FOXO Inhibition.

Figure 7

(A) BM cells recovered from mice that succumbed to MLL-AF9-induced AML (refer to Figure 5F) that were wild-type or null for FoxO1/3/4 were subjected to western blotting with pc-JunS63 and Tubulin antibodies.

(B) BM cells recovered from mice that succumbed to control or myr-Akt-expressing MLL-AF9-in-duced AML (refer to Figure S5G) were subjected to western bloting with antibodies that recognize Akt, Tubulin, or the phosphorylated forms of FoxO3 (pFoxO3S256) or c-Jun (pc-JunS63) antibodies.

(C) Mean expression levels of FOXO1, FOXO3, and c-JUN in the FOXO signature-based, hierarchical cluster-defined primary AML sample groups (p < 0.0001; see Figure 4G). Data are represented in a box plot with whiskers.

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