TABLE 1.

Association between soluble CD14 and other cardiovascular risk factors and measures of subclinical cardiovascular disease at the CHS baseline exam

Baseline Characteristic	Model A Beta ± SE	Model B Beta ± SE	Model C Beta ± SE
Age (years)	7.13 ± 0.86*	6.60 ± 0.88*	4.34 ± 0.90*
Female sex	119 ± 9.7*	123 ± 9.6*	118 ± 10.3*
African American race	−155 ± 13.3*	−164 ± 13.5*	−185 ± 13.3*
Current smoking	96 ± 15*	84 ± 15*	41 ± 15**
Diabetes	59 ± 10*	66 ± 11*	35 ± 11**
Hypertension	74 ± 10*	78 ± 10*	54 ± 10*
Systolic blood pressure (mm Hg)	0.49 ± 0 .22	0.26 ± 0.22	0.18 ± 0.22
LDL cholesterol (mg/dL)	0.34 ± 0.12	0.44 ± 0.13**	0.43 ± 0.13**
HDL cholesterol (mg/dL)	−1.02 ± 0.32**	−0.96 ± 0.34**	0.38 ± 0.34
Triglycerides (mg/dL)	17.1 ± 11.1	4.62 ± 11.54	−30 ± 13.4
Glucose (mg/dL)	1.07 ± 0.13*	1.00 ± 0.16*	0.73 ± 0.16*
Insulin (mg/dL)	0.84 ± 0.18*	0.70 ± 0.18*	0.40 ± 0.18
BMI (kg/m2)	−4.87 ± 1.03*	−4.87 ± 1.03*	−13.0 ± 1.12*
Waist circumference (cm)	−1.14 ± 0.38**	0.316 ± 0.674	−1.15 ± 0.658
C-reactive protein (g/L)	95 ± 4.5*	101 ± 4.7*	62 ± 6.0*
Interleukin-6 (pg/dL)	117 ± 7.8*	117 ± 8.1*	51 ± 9.3*
Fibrinogen (mg/dL)	1.28 ± 0.069*	1.26 ± 0.070*	0.55 ± 0.085*
Internal carotid wall thickness (mm)	75.6 ± 8.80*	55.6 ± 8.98*	36.7 ± 8.96*
Ankle-brachial index	−273 ± 27.8 *	−198 ± 28.9*	−113 ± 29.1*

Triglycerides, C-reactive protein, and interleukin-6 were natural log-transformed.

Model A: adjusted for age, race, and sex.

Model B: adjusted for age, race, sex, smoking, diabetes, hypertension, systolic blood pressure, BMI.

Model C: adjusted for age, race, sex, smoking, diabetes, hypertension, systolic blood pressure, BMI, LDL cholesterol, HDL cholesterol, C-reactive protein, interleukin-6, and fibrinogen.

In all models, the estimates for age, race, and sex were adjusted only for the two remaining variables.

^*P<0.0001

^**P<0.01