Table 2.
Top genome-wide association results for soluble CD14 in European Americans and African Americans
| Population | Chromosome | Number SNPS with P<5×10−8 |
Top SNP in region |
Position Hg18 |
Candidate genes | Minor allele | Minor allele frequency |
Effect size (Standard Error) [ng/mL sCD14] |
P-value |
|---|---|---|---|---|---|---|---|---|---|
| European- Americans |
5q31 | 144 | rs5744441 | 139997031 |
HBEGF, SLC4A9,
ANKHD1, EIF4EBP3, SRA1, APBB3, SLC35A4, CD14, IK, WDR55, TMCO6, DND1, HARS, HARS2, NDUFA2,ZMAT2, VTRNA1 |
G | 0.22 | −101 (10) | 2.98 × 10−23 |
| African- Americans |
5q31 | 1 | rs778584 | 139985396 | CD14 | T | 0.31 | 128 (24) | 5.5 × 10−9 |
| European- Americans |
1q24 | 19 | rs1063412 | 170677590 | PIGC | A | 0.43 | −48 (8.5) | 1.40 × 10−8 |