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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Nov 15;33(1):10.1161/ATVBAHA.112.300421. doi: 10.1161/ATVBAHA.112.300421

Table 4.

Estimated hazard ratios for association between 1 standard deviation unit increase in soluble CD14 and incident CVD events and mortality

Mortality (n=3,820 ) MI (n=870) CHD (n=1,547) Stroke (n=945)
Model HR (95%CI) P HR (95%CI) P HR (95%CI) P HR (95%CI) P
Minimal (1) 1.25
(1.21, 1.29)		 1.2 × 10−42 1.10
(1.03, 1.19)		 0.006 1.14
(1.09, 1.20)		 2.4 × 10−7 1.15
(1.07, 1.23)		 5.2 × 10−5
Multivariable (2) 1.11
(1.07, 1.15)		 5.5 × 10−9 1.07
(0.99, 1.15)		 0.075 1.11
(1.06, 1.18)		 7.5 × 10−5 1.12
(1.04, 1.20)		 0.002
Subclinical (3) 1.09
(1.06, 1.13)		 1.3 × 10−6 1.03
(0.96, 1.11)		 0.38 1.07
(1.01, 1.13)		 0.017 1.11
(1.03, 1.19)		 0.004
Biomarkers (4) 1.09
(1.05, 1.13)		 2.9 × 10−5 0.96
(0.89, 1.05)		 0.39 1.01
(0.95, 1.07)		 0.73 1.08
(1.00, 1.17)		 0.041

Model Definitions: 1) Age, sex, race

2) Model 1 + smoking, diabetes, hypertension, SBP, LDL (baseline CVD, cystatin C)

3) Model 2 + carotid IMT and ankle-brachial index

4) Model 3 + C-reactive protein, interleukin-6, and fibrinogen