Table 1.
All patients |
Age ≦40 |
Age >40 |
p* | |
---|---|---|---|---|
(n = 61) | (n = 23) | (n = 38) | ||
Patient demographics | ||||
Age (years) (median; 25 and 75 percentiles) (range) |
47.5; 36.5-60.2 (26-75.7) |
35.5; 30.8-37.0 (26-39.5) |
56.8; 50.6-64.3 (40.8-75.7) |
<0.001 |
Sex (M:F) |
54:7 |
19:4 |
35:3 |
0.409 |
Albumin (g/dL) (median; 25 and 75 percentiles) |
4.0; 3.8-4.4 |
4.2; 3.9-4.4 |
4.0; 3.7-4.3 |
0.129 |
Total bilirubin (mg/dL) (median; 25 and 75 percentiles) |
0.80; 0.6-1.2 |
0.7; 0.5-1.1 |
0.9; 0.6-1.2 |
0.688 |
ALT (U/L) (median; 25 and 75 percentiles) |
41.0; 30.5-57.0 |
46.0; 35.0-61.0 |
38.0; 29.8-57.0 |
0.946 |
AST (U/L) (median; 25 and 75 percentiles) |
40.0; 27.0-66.0 |
42.0; 27.0-65.0 |
39.5; 27.0-67.5 |
0.871 |
Platelet (/mm3) (median; 25 and 75 percentiles) |
182000; 139000-224500 |
204000; 171000-264000 |
167000; 131750-2017250 |
0.087 |
ICG-15R (%) (retention rate) (median; 25 and 75 percentiles) |
8; 5.3-12.8 |
6; 4-8 |
10; 6-14.3 |
0.0055 |
Child-Pugh A/B (%) |
59/2 (96.7%/3.3%) |
22/1 (95.7%/4.4%) |
37/1 (97.4%/2.6%) |
1.000 |
Tumor characteristics | ||||
Tumor size (cm) (median; 25 and 75 percentiles) |
4.8; 3.4-8.7 |
5.0; 4.0-11.0 |
4.4; 3.2-6.4 |
0.523 |
Multinodularity (%) |
28 (45.9%) |
9 (39.1%) |
19 (50.0%) |
0.440 |
AFP (ng/ml) (median; 25 and 75 percentiles) |
190; 15-1541 |
316; 18.4-5499 |
169.5; 12.9-728.5 |
0.742 |
Macroscopic venous invasion (%) |
18 (29.5%) |
14 (60.9%) |
4 (10.5%) |
<0.001 |
Daughter nodule (%) |
32 (62.8%) |
11 (55.0%) |
21 (67.7%) |
0.389 |
Histopathological findings | ||||
Cirrhosis in non-tumor part (yes/no) (%) |
33/28 (54.1%/45.9%) |
4/19 (17.4%/82.6%) |
24/14 (63.2%/36.8%) |
<0.001 |
Edmondson grading (I or II/ III or IV) (%) |
33/24 (57.9%/42.1%) |
11/12 (47.8%/52.2%) |
22/12 (64.7%/35.3%) |
0.276 |
Microscopic venous invasion (%) | 43 (70.5%) | 17 (73.9%) | 26 (68.4%) | 0.775 |
ICG-15R: indocyanine green retention rate at 15 minutes;
*p value: comparison between younger and elderly HCC patients.