Fig. 4.

Premethacholine (left) and postmethacholine (right) images from separate days on the same patient, with baseline day 1 are on top and day 2 (17 days later) at bottom. Two defects in the same location are observed in the left lung at baseline on both days. On day 1, the one large defect resolved (curved arrow) after methacholine, another decreased (straight arrow), and small new defects developed (one marked by arrowhead). On day 2, the two defects in the left lung remained unchanged after methacholine. A large new defect (short thick arrow) developed on the right and a small defect (open arrow) occurred close to the one marked by the arrowhead on day 1. Reproduced from de Lange et al. [33] with permission of Elsevier.