Table 1. Summary of chromosomal aberrations observed in blood lymphocyte metaphases of PALB2 c.1592delT mutation carriers and healthy controls.

Type of aberration	Mean of chromosomal aberrations observed per 100 metaphases		P-value*
	Carriers (n=6)	Controls (n=9)
Telomeric associations	0.65 (SE=0.41)	—	0.328
Chromatid/chromosome breaks, deletions	1.65 (SE=1.07)	1.67 (SE=0.49)	0.689
Simple chromosomal rearrangements†	5.92 (SE=2.19)	0.67 (SE=0.33)	0.036‡
Complex chromosomal rearrangements§	2.92 (SE=1.76)	—	0.036‡
Total rearrangements (simple+complex)	8.83 (SE=3.75)	0.67 (SE=0.33)	0.018‡

^*Mann–Whitney U-test.

^†Inversions, ring chromosomes, translocations (≤3 break rearrangements).

^‡Statistically significant P-value (<0.05).

^§Translocations (≥4 break rearrangements) and marker chromosomes.