Fig. 12.

Alignment of the amino acid sequences of rat, mouse, and human FADS1, FADS2, and FADS3 deduced from their nucleotide sequences. In the N-terminal end, the cytochrome b5-like domain (present in FADS1, FADS2, and FADS3 sequences) is surrounded by the blue box and characterized by a HPGG motif (black box). In the carboxyl-terminal end, the desaturase domain is characterized by three histidine boxes (red) that are necessary for the catalytic activity, which are present in all the sequences shown.