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. 2013 Nov 8;8(11):e78715. doi: 10.1371/journal.pone.0078715

Figure 5. Redefining the core of eIF3 and proposed models for assembly.

Figure 5

(A) Venn diagram highlighting common subunits among three definitions of the eIF3 core complex: 1) the phylogenetically conserved complex from S. cerevisiae, 2) the reconstituted human PCI-MPN core complex and 3) the biologically essential subunits from N. crassa eIF3. (B) Proposed models for human-like eIF3 assembly. Individual subunits or sub-complexes assemble onto an ac dimer. Solid and dashed arrows represent assembly and alternative assembly interactions and are drawn to reconcile the compositional breadth of eIF3 sub-complexes across species as well as biochemical data [12], [47].