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. Author manuscript; available in PMC: 2013 Nov 13.
Published in final edited form as: Curr Opin Struct Biol. 2011 Jan 20;21(1):10.1016/j.sbi.2010.11.007. doi: 10.1016/j.sbi.2010.11.007

Figure 1.

Figure 1

(a) Conformations of the (retro-)translocating ribosome identified by cryo-EM. The individual complexes are classified by tRNA position. A reconstruction of a representative sub-state from the ensemble of sub-states for each pre- and post-translocational state (pre1 to pre5 and post1 to post3) is shown, along with a schematic representation of tRNA position. (b) Thermodynamics of translocation based on population analysis of the states identified by cryo-EM. The data indicate that conversion globally from the post- to pre-translocation state, while sub-states within the post- and pre- categories are in rapid equilibrium with each other. Reproduced with permission from Fischer et al., 2010.