Skip to main content
. Author manuscript; available in PMC: 2013 Nov 13.
Published in final edited form as: Nat Cell Biol. 2011 Aug 1;13(8):10.1038/ncb2312. doi: 10.1038/ncb2312

Figure 1.

Figure 1

Positive regulators of centriole duplication are regulated by degradation. In this issue, Malek and colleagues provide evidence for FBXW5-induced degradation of HsSAS-6. FBXW5 activity seems to be inhibited by PLK4-mediated phosphorylation of residue Ser 151 of FBXW5. FBXW5 levels in G1 are kept low by the APC/C, which also induces the degradation of HsSAS-6 in G1 (ref. 8). In addition to FBXW5 and itself, other targets of mammalian PLK4 remain unknown. Cyclin F induces CP110 degradation during G2 to prevent centriole overduplication. Cyclin E levels and activity are controlled directly by FBXW7 and indirectly by SKP2 through regulation of p27, an inhibitor of Cyclin E–CDK complexes. Red lines denote degradation processes. E3 ligases and F-box proteins are indicated in red.