Table 1.
The fatty acid content and ratios in the mice liver
| Fatty acid | WT-control | WT-HFD | Nrf2-null-control | Nrf2-null-HFD |
|---|---|---|---|---|
| C12: 0 |
0.07 ± 0.01 |
0.07 ± 0.01 |
0.07 ± 0.01 |
0.08 ± 0.01** |
| C14: 0 |
0.14 ± 0.01 |
0.13 ± 0.01 |
0.22 ± 0.02$$ |
0.19 ± 0.02$$ |
| C15: 0 |
0.12 ± 0.01 |
0.13 ± 0.01 |
0.12 ± 0.01 |
0.14 ± 0.01* |
| C16: 0 |
5.64 ± 0.48 |
10.56 ± 0.78** |
5.98 ± 0.54 |
11.59 ± 0.95** |
| C17: 0 |
0.07 ± 0.01 |
0.11 ± 0.01** |
0.08 ± 0.01 |
0.12 ± 0.01** |
| C18: 0 |
4.17 ± 0.28 |
5.10 ± 0.41* |
4.30 ± 0.37 |
5.46 ± 0.49* |
| C18: 1 |
7.46 ± 0.64 |
13.35 ± 1.16** |
7.66 ± 0.67 |
17.40 ± 1.36**$$ |
| c18: 2 |
5.13 ± 0.39 |
7.34 ± 0.59** |
5.30 ± 0.39 |
8.13 ± 0.68** |
| C18: 3 |
0.03 ± 0.00 |
0.03 ± 0.00 |
0.03 ± 0.00 |
0.04 ± 0.00* |
| C20: 0 |
0.08 ± 0.01 |
0.10 ± 0.01 |
0.09 ± 0.01 |
0.15 ± 0.01**$$ |
| C20: 1 |
0.08 ± 0.01 |
0.10 ± 0.01** |
0.08 ± 0.01 |
0.12 ± 0.01**$ |
| C20: 2 |
0.18 ± 0.01 |
0.31 ± 0.03** |
0.19 ± 0.02 |
0.32 ± 0.03** |
| C20: 3 |
0.29 ± 0.03 |
0.38 ± 0.03** |
0.30 ± 0.03 |
0.40 ± 0.03** |
| C20: 4 |
2.55 ± 0.21 |
3.26 ± 0.31** |
2.74 ± 0.03 |
3.46 ± 0.32* |
| C22: 0 |
0.02 ± 0.00 |
0.03 ± 0.01* |
0.03 ± 0.00 |
0.05 ± 0.01**$$ |
| C22: 6 |
0.85 ± 0.06 |
0.57 ± 0.03** |
0.68 ± 0.05 |
0.64 ± 0.05 |
| TFA |
26.88 ± 2.17 |
41.57 ± 3.41** |
27.87 ± 2.38 |
48.31 ± 3.99**$ |
| SFA |
10.32 ± 0.75 |
16.23 ± 1.18** |
10.89 ± 0.91 |
17.79 ± 1.44** |
| UFA |
16.56 ± 0.91 |
25.34 ± 1.56** |
16.98 ± 1.28 |
30.51 ± 2.30**$ |
| PUFA |
9.03 ± 0.36 |
11.90 ± 0.49** |
9.25 ± 0.63 |
12.99 ± 0.98** |
| MUFA |
7.53 ± 0.63 |
13.45 ± 1.15** |
7.73 ± 0.68 |
17.52 ± 1.36**$$ |
| SFA/TFA ratio (%) |
38.37 ± 0.57 |
39.08 ± 0.37 |
39.24 ± 0.54 |
36.83 ±0.36**$$ |
| UFA/TFA ratio (%) |
61.62 ± 0.57 |
60.97 ± 0.37 |
60.93 ± 0.54 |
63.16 ± 0.36**$$ |
| PUFA/SFA ratio (%) |
87.69 ± 4.63 |
73.45 ± 3.39** |
85.05 ± 3.57 |
73.07 ± 2.42** |
| MUFA/SFA ratio (%) |
72.99 ± 0.83 |
82.80 ± 1.11** |
71.02 ± 0.34 |
98.48 ± 0.34**$$ |
| n-6 / n-6 ratio (%) | 49.94 ± 6.59 | 43.49 ± 5.78 | 50.47 ± 2.98$$ | 42.65 ± 3.89* |
Asterisks * represent statistical difference caused by HFD within WT and null-Nrf2 groups; dollar signs $ represent statistical difference from WT and null-Nrf2 on the same diet. 0.05 < P values < 0.01 (*, $). P values < 0.01 (**, $$).
All of the values are expressed as mean ± standard deviation (SD) (n = 20 per treatment group). TFA, total fatty acid; SFA, saturated fatty acid; UFA, unsaturated fatty acid; PUFA, polyunsaturated fatty acid; MUFA, monounsaturated fatty acid; n-6/n-6 ratio, C20: 4/C18: 2.