Table 2.
Sequence identity and entry efficiency of V1V2 inter- and intrasubtypes chimeras
| Sequence identity (%) | Viral entry (%) | SD (%) | ||
|---|---|---|---|---|
| Intersubtype |
A/B |
51.2 |
141.5 |
52.2 |
| |
A/C |
56.4 |
29.1 |
9.2 |
| |
A/G |
48.8 |
72.5 |
23.0 |
| |
B/C |
46.4 |
1.1 |
1.0 |
| |
B/C3 |
45.7 |
0.5 |
0.3 |
| |
B/G |
47.5 |
3.2 |
3.6 |
| Intrasubtype |
A/A1 |
66.7 |
69.4 |
38.6 |
| |
A/A2 |
62.8 |
115.9 |
20.1 |
| |
C/C1 |
60.0 |
1.2 |
0.6 |
| |
C/C2 |
50.0 |
2.8 |
1.5 |
| |
C/C3 |
57.5 |
0.9 |
0.6 |
| G/G1 | 54.1 | 257.1 | 27.4 |
In all cases, the values are given relative to those observed for the corresponding wild-type receiver protein. The results for viral entry represent the mean values derived from 3 to 5 independent experiments. SD, standard deviation.