Table 2.

Efficacy of intralesional therapy evaluated by randomized trials

Treatment	Study	Mode of study	Effect
Corticosteroids	Cipollone et al52	Placebo-controlled, single-blind	No significant difference between treatment and placebo
Collagenase	Gelbard et al56	Placebo-controlled, double-blind	Decreased curvature and plaque size
Verapamil	Rehman et al63	Placebo-controlled, single-blind	No significant difference between treatment and placebo
Interferons	Judge et al69	Placebo-controlled, single-blind	Significant improvement in penile curvature, plaque size, penile pain, and erectile function
	Hellstrom et al70	Placebo-controlled, single-blind