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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Hypertension. 2013 Jul 1;62(3):10.1161/HYPERTENSIONAHA.113.01449. doi: 10.1161/HYPERTENSIONAHA.113.01449

Figure 6. BQ123 reversed chronic hypoxia-induced impairment of trophoblast invasion and spiral artery remodeling.

Figure 6

Placentas were obtained in hypoxic and normoxic control pregnant rats at day 21 of gestation, in the absence or presence of BQ123. A, The representative implantation site including the placenta and its associated mesometrial triangle stained with cytokeratin (×40). A spiral arterial channel is crossing the placenta. B, Representative Periodic acid Schiff (PAS) staining of fibrinoid (solid arrows), cytokeratin (CK) staining of trophoblast invasion (solid arrowheads), and α-actin staining of vascular smooth muscle (hollow arrows) in spiral arteries in the mesometrial triangle (×200). C, The percentage of fibrinoid, trophoblast, and vascular smooth muscle (VSM) of total spiral artery contour length was determined. Data are means ± SEM, n = 49–53. * P < 0.05 versus normoxia.