Table 2.

Minor allele frequencies (MAF), rate ratio and 95% confidence intervals of CHD according to NFKB1 ins/del polymorphism in the Diet, Cancer and Health (DCH) study, the Health Professionals Follow Up Study (HPFS) and Nurses’ Health Study (NHS).

	MAF (s.e)		N (cases/controls)			Rate ratio (95% confidence interval)
NFKB1 genotype	Cases	Control	Ins/Ins	Ins/Del	Del/Del	Ins/Ins	Ins/Del	p	Del/Del	p	Del-carrier (dominant model)	p
DCH men	0.41 (0.01)	0.37 (0.01)	268/352	368/395	133/123	1.0	1.23 (0.97–1.55)	0.09	1.54 (1.12–2.13)	0.008	1.30 (1.04-1.63)	0.02
DCH women	0.39 (0.02)	0.39 (0.01)	92/289	110/365	37/119	1.0	1.17 (0.80–1.73)	0.42	1.00 (0.581.72)	1.00	1.13 (0.78-1.62)	0.52
HPFS (men)	0.39 (0.02)	0.38 (0.02)	154/346	217/389	57/140	1.0	1.24 (0.96–1.61)	0.05	0.93 (0.64–1.35)	0.24	1.16 (0.91-1.48)	0.29
NHS (women)	0.40 (0.02)	0.38 (0.01)	164/336	200/370	75/139	1.0	1.22 (0.93–1.59)	0.58	1.29 (0.89–1.85)	0.39	1.23 (0.96-1.59)	0.11
Pooled men†	0.40	0.38	422/698	585/784	190/263	1.0	1.24 (1.04–1.47)	0.02	1.21 (0.73–1.99)	0.46	1.23 (1.05-1.46)	0.01
Pooled women†	0.39	0.39	256/625	310/735	112/258	1.0	1.20 (0.96–1.50)	0.11	1.19 (0.88–1.61)	0.26	1.20 (0.97-1.48)	0.09
Pooled men and women†	0.40	0.38	678/1323	895/1519	302/521	1.0	1.22 (1.07–1.40)	0.004	1.20 (0.94–1.53)	0.14	1.22 (1.07-1.39)	0.003

^*Cox proportional hazard regression models in DCH (stratified by sex). Conditional logistic regression models were run in HPFS data (stratified by matching factors; age, smoking, blood draw). All models are adjusted for BMI, alcohol intake, NSAID use, hypertension, diabetes and hypercholesterolemia (age and smoking in DCH).

^†Meta-analysis using random effects model.