Table 1. Baseline characteristics of the participants in different quartiles of uric acid levels.
| Uric Acid Quartiles (mg/dL*) | |||||
| ≤4.5 | 4.5–5 | 5–6 | >6 | P for trend** | |
| (n = 1257) | (n = 1210) | (n = 1263) | (n = 1245) | ||
| Age, mean (SD † ), y | 69.1(8.9) | 70.4(9.2) | 70.4(9.0) | 71.5(9.4) | <0.001 |
| Men (%) | 208 (16.5) | 374(30.9) | 586(46.4) | 705(56.6) | <0.001 |
| Smoking | |||||
| Current (%) | 312(24.8) | 277(22.9) | 313(24.8) | 245(19.7) | 0.001 |
| Former (%) | 366(29.1) | 429(35.5) | 529(41.9) | 614(49.3) | |
| Daily Alcohol Intake in drinkers, median (Interquartile range), g/d | 4.5(0.7–13.6) | 5.0(1.0–14.8) | 9.3(1.7–21.2) | 11.2(2.5–27.9) | <0.001 |
| Body mass index, mean (SD), kg/m2 | 25.2(3.4) | 25.7(3.5) | 26.6(3.6) | 27.3(3.8) | <0.001 |
| Waist circumference, mean (SD), cm | 84.8(10.8) | 87.7(10.3) | 91.7(10.2) | 94.8(10.5) | <0.001 |
| Total cholesterol, mean (SD), mmol/L | 6.6(1.2) | 6.5(1.2) | 6.6(1.3) | 6.6(1.2) | 0.472 |
| HDL cholesterol, mean (SD), mmol/L | 1.4(0.3) | 1.3(0.3) | 1.3(0.3) | 1.2(0.3) | <0.001 |
| C-reactive protein, median (Interquartile range), mg/L | 1.3(0.6–2.7) | 1.8(0.9–3.4) | 2.0(1.0–3.8) | 2.5(1.2–4.6) | <0.001 |
| Glomerular filtration rate, mean (SD), ml/min per 1.73 m2 | 82.9(16.8) | 78.3(15.4) | 76.1(16.3) | 71.1(18.2) | <0.001 |
| Systolic blood pressure, mean (SD), mm Hg | 137.3(22.2) | 138.3(21.7) | 139.3(21.5) | 141.2(22.4) | <0.001 |
| Diastolic blood pressure, mean (SD), mm Hg | 72.6(11.5) | 72.8(11.6) | 73.4(11.6) | 74.0(12.1) | 0.091 |
| Chronic kidney disease (%) | 65(5.2) | 116(9.6) | 173(13.7) | 331(26.6) | <0.001 |
| Diabetes Mellitus (%) | 136(10.9) | 109(9.1) | 125(9.9) | 178(14.4) | <0.001 |
| History of coronary heart disease (%) | 88(7.1) | 121(10.2) | 193(15.4) | 264(21.6) | <0.001 |
| Diuretics (%) | 101(8.0) | 125(10.3) | 189(15.0) | 413(33.2) | <0.001 |
| Calcium channel blockers (%) | 52(4.1) | 46(3.8) | 75(5.9) | 131(10.5) | <0.001 |
| Beta-blockers (%) | 103 (8.2) | 134(11.1) | 192(15.2) | 293(23.5) | <0.001 |
| ACE inhibitors (%) | 41(3.3) | 33(2.7) | 61(4.8) | 126(10.1) | <0.001 |
*
To convert to SI unit multiply by 59.48.
**
P-value adjusted for age and sex for continuous measure of uric acid.
†
Standard Deviation.